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Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 316-327 doi: 10.1007/s11684-013-0269-z

Abstract:

Diffuse cystic lung diseases are uncommon but can present a diagnostic challenge because increasing“Diffuse” distribution in the lung implies involvement of all lobes.Diffuse lung involvement with cystic lesions can be seen in pulmonary lymphangioleiomyomatosis, pulmonarydisease.important clues to defining the underlying nature of the cystic lung disease and guide diagnostic evaluation

Keywords： cyst     lung disease     interstitial lung disease     lymphangioleiomyomatosis     Langerhans’ cell histiocytosis     Birt-Hogg-Dubé    

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Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 395-405 doi: 10.1007/s11684-012-0231-5

Abstract:

Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during theirAlthough surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuselung disease, it is also associated with higher morbidity and mortality than alternative, less invasivea safe and effective method for establishing the diagnosis of LAM, obviating the need for surgical lung

Keywords： lymphangioleiomyomatosis     lymphangiomyomatosis     multicystic lung disease     diffuse cystic lung disease     transbronchial    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: The current organ allocation rules prioritize elderly and urgent patients on the lung transplantationThis retrospective cohort study recruited 166 lung transplant recipients aged ≥ 65 yearsGroup D restrictive lung disease was the main indication of a lung transplant in recipients over 65 years

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Ambient air pollution and lung disease in China: health effects, study design approaches and future research

Jeffrey H. Mandel,Christine Wendt,Charles Lo,Guangbiao Zhou,Marshall Hertz,Gurumurthy Ramachandran

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 392-400 doi: 10.1007/s11684-015-0397-8

Abstract: This fraction has been associated with increasing rates of cardio-respiratory disease in China and elsewhereLung cancer mortality in China has increased since the 1970s and has been higher in men and in urban

Keywords： air pollution     PM2.5     lung disease     study design     epidemiology    

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mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient with cystic

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: Cystic fibrosis (CF) is a rare autosomal recessive disease with only one pathogenic gene cystic fibrosis

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 550-558 doi: 10.1007/s11684-017-0567-y

Abstract:

Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembraneCF is characterized by recurrent pulmonary infection with obstructive pulmonary disease.

Keywords： cystic fibrosis     pseudo-Bartter syndrome     hypokalemic alkalosis     CFTR gene     mutations     infants     diagnosis    

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Diagnosis and management against the complications of human cystic echinococcosis

Hao WEN, Tuerganaili AJI, Ying-Mei SHAO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 394-398 doi: 10.1007/s11684-010-0180-9

Abstract: Cystic echinococcosis (CE) (hydatidosis, hydatid disease) is a zoonosis caused by the larval stage ofHepatic cystic echinococcosis (HCE) is often asymptomatic, and symptoms occur largely when complications

Keywords： cystic echinococcosis     complication     diagnosis     treatment    

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Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 616-623 doi: 10.1007/s11783-013-0589-x

Abstract: analysis of spatially referred information, GIS has been recognized as a method to aid the modeling of diffuseA common question in integrating diffuse pollution models and GIS is to choose a suitable coupling approach, in which the feature of diffuse pollution models should be taken into account.In this paper, we report on our experience in coupling a distributed diffuse pollution model with a GISexecution and more robust than loose and tight coupling approaches and is suitable for distributed diffuse

Keywords： diffuse pollution     GIS     modeling     nutrients     phosphorus    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: achieved 40%–50% long-term complete response in relapsed or refractory diffusepatients, seven achieved complete remission, 10 experienced partial remissions, while four had stable diseaseand in vitro anti-tumor functions of CAR-T cells, leading to CAR-T cell therapy failure and diseaseImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansion and disease

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 228-232 doi: 10.1007/s11684-016-0447-x

Abstract:

Lung cancer contributes substantially to the global burden of disease and healthcare costs.Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lungThe International Agency for Research on Cancer has identified several lung carcinogens, which we believeTo curb the societal burden of lung cancer, healthcare resources need to be focused on early detectionlung cancer.

Keywords： lung cancer     screening     risk factors     environmental    

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Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 420-431 doi: 10.15302/J-FASE-2018243

Abstract:

Various process-based models are extensively being used to analyze and forecast catchment hydrology and water quality. However, it is always important to select the appropriate hydrological and water quality modeling tools to predict and analyze the watershed and also consider their strengths and weaknesses. Different factors such as data availability, hydrological, hydraulic, and water quality processes and their desired level of complexity are crucial for selecting a plausible modeling tool. This review is focused on suitable model selection with a focus on desired hydrological, hydraulic and water quality processes (nitrogen fate and transport in surface, subsurface and groundwater bodies) by keeping in view the typical lowland catchments with intensive agricultural land use, higher groundwater tables, and decreased retention times due to the provision of artificial drainage. In this study, four different physically based, partially and fully distributed integrated water modeling tools, SWAT (soil and water assessment tool), SWIM (soil and water integrated model), HSPF (hydrological simulation program– FORTRAN) and a combination of tools from DHI (MIKE SHE coupled with MIKE 11 and ECO Lab), have been reviewed particularly for the Tollense River catchment located in North-eastern Germany. DHI combined tools and SWAT were more suitable for simulating the desired hydrological processes, but in the case of river hydraulics and water quality, the DHI family of tools has an edge due to their integrated coupling between MIKE SHE, MIKE 11 and ECO Lab. In case of SWAT, it needs to be coupled with another tool to model the hydraulics in the Tollense River as SWAT does not include backwater effects and provision of control structures. However, both SWAT and DHI tools are more data demanding in comparison to SWIM and HSPF. For studying nitrogen fate and transport in unsaturated, saturated, and river zone, HSPF was a better model to simulate the desired nitrogen transformation and transport processes. However, for nitrogen dynamics and transformations in shallow streams, ECO Lab had an edge due its flexibility for inclusion of user-desired water quality parameters and processes. In the case of SWIM, most of the input data and governing equations are similar to SWAT but it does not include water bodies (ponds and lakes), wetlands and drainage systems. In this review, only the processes that were needed to simulate the Tollense River catchment were considered, however the resulted model selection criteria can be generalized to other lowland catchments in Australia, North-western Europe and North America with similar complexity.

Keywords： diffuse pollution     ECO Lab     HSPF     lowland catchment     MIKE 11     MIKE SHE     modeling tools     SWAT     SWIM     Tollense River    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Here, we demonstrate the involvement of FRMD6 in lung cancer progression.We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues.In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lungsquamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, lung cancer progression by activating the mTOR

Keywords： FRMD6     lung cancer     mTOR pathway    

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Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 344-349 doi: 10.1007/s11684-015-0399-6

Abstract:

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significantpresented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lungOur findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lungcancer, which can lead to lung fiber hyperplasia.

Keywords： Yunnan tin mine     miners     lung cancer    

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The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 388-394 doi: 10.1007/s11684-012-0233-3

Abstract: Unfortunately, the lung cancer morbidity and mortality rates in this region are among China’s highestIn 2004–2005, the crude death rate of lung cancer was 91.3 per 100 000 in the whole Xuanwei CityThe epidemiologic distribution (clustering patterns by population, time, and space) of lung cancer inThe main factor that associates with a high rate of lung cancer incidence was found to be indoor airTaken together, lung cancer in this smoky coal combustion region is a unique model for environmental

Keywords： lung cancer     Xuanwei     smoky coal combustion     polycyclic aromatic hydrocarbons     epidemiology    

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Title Author Date Type Operation

Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Journal Article

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Ambient air pollution and lung disease in China: health effects, study design approaches and future research

Jeffrey H. Mandel,Christine Wendt,Charles Lo,Guangbiao Zhou,Marshall Hertz,Gurumurthy Ramachandran

Journal Article

mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient with cystic

Journal Article

Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Journal Article

Diagnosis and management against the complications of human cystic echinococcosis

Hao WEN, Tuerganaili AJI, Ying-Mei SHAO,

Journal Article

Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Journal Article

Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Journal Article

The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Journal Article